A phase II trial of TBL-12 sea cucumber extract in patients with untreated asymptomatic myeloma
نویسندگان
چکیده
منابع مشابه
A phase II trial of TBL-12 sea cucumber extract in patients with untreated asymptomatic myeloma.
The sphingolipids/glycosides in sea cucumbers have several antitumour properties (Zou et al, 2003) including antiangiogenesis (Tian et al, 2005), direct tumour cytotoxicity (Sugawara et al, 2006) and, of particular relevance to multiple myeloma (MM), the inhibition of osteoclastogenesis (Kariya et al, 2004). TBL-12, a sea cucumber extract, has been commercially available since 1981 and has been...
متن کاملarsenic trioxide in patients with refractory multiple myeloma: a prospective, phase ii, single-arm study
multiple myeloma (mm) characterized by proliferation of plasma cells in bone marrow and production of monoclonal immunoglobulin's. recently, arsenic trioxide (ato), has been considered for treatment refractory mm. we assessed the safety and efficacy of ato for patients with refractory mm. a phase 2, study of arsenic trioxide was conducted in 12 mm patients, whose refractory to two standard ther...
متن کاملA randomized phase II trial comparing chemoimmunotherapy with or without bevacizumab in previously untreated patients with chronic lymphocytic leukemia
Bevacizumab is a monoclonal antibody targeting vascular endothelial growth factor (VEGF) with in vitro pro-apoptotic and antiangiogenic effects on chronic lymphocytic leukemia (CLL) cells. As monotherapy in patients with CLL, it has no clinical activity. Here we report the results of an open-label, randomized phase II trial comparing the combination of pentostatin, cyclophosphamide and rituxima...
متن کاملrandomized controlled trial study about compare of post operative pain after milligan morgan versus submucosal hemorrhoidectomy with & without pudendal nerve marcaine block in patients that had hemorrhoidectomy in imam hossein hospital of shahrood in 1389-90
مقدمه:هموروئید یکی از شایعترین بیماریهای جراحی ناحیه آنورکتال است که با درد و خونریزی بروز می کند. کاهش دردبعد عمل علاوه بر افزایش رضایت بیمار باعث کاهش مدت بستری و کاهش بار تحمیلی بر روی اقتصاد جامعه می گردد. مطالعه حاضر مقایسه ای از لحاظ میزان درد و میزان تأثیر مارکائین به عنوان روشی برای پروفیلاکسی درد بعداز عمل،دو روش هموروئیدکتومی باز و بسته انجام می دهد. مواد وروشها: این مطالعه کارآزمایی...
ذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2016
ISSN: 0007-1048
DOI: 10.1111/bjh.14314